Beilstein J. Org. Chem.2017,13, 845–854, doi:10.3762/bjoc.13.85
terpene producing Escherichia coli, this review shall give an insight in recent progresses regarding manipulation of mostly diterpene synthases.
Keywords: enzyme engineering; heterologous production in E. coli; metabolic pathway optimization; modular biosynthesis; plantditerpenes; Introduction
plantditerpenes in well-established recombinant hosts, such as Escherichia coli [21][22][23]. Recent developments in this field will be reviewed in this work.
Review
Biosynthesis of diterpenes and transfer to heterologous production system
Integration of biosynthetic gene clusters from plants into a
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Graphical Abstract
Scheme 1:
Isoprenoid biosynthetic pathways and examples for their engineering in heterologous production syst...